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Photos: Inside a supercomputer lab
Photo Another one of the lab's supercomputers, this is IBM's Blue Gene, currently rated the 74th most powerful computer in the world, at 28 teraflops. This photo story is a peek into one of the world's great supercomputer labs housed inside the US's Oak... [14 Jul 2008]
Delivering Information Intelligently Featuring Gartner’s Gene Phifer and CA’s Gary Starkey
White Paper Join Gartner Analyst, Gene Phifer and CA’s, Senior Vice President and General Manager for CleverPath Portal and Business Intelligence solutions, Gary Starkey, as they discuss the evolution and emergence of the Smart Enterprise Suite and CA's... [03 Jul 2008]
Maximum Likelihood Analysis of Adaptive Evolution in HIV-1 Gp120 ENV Gene
White Paper This paper applies the likelihood models to analyze a data set of 186 HIV-1 gp120 env gene sequences for comparison with a previous analysis of the same data set. The maximum likelihood analysis identified a number of sites under positive selection... [03 Jul 2008]
Mutual Information Analysis as a Tool to Assess the Role of Aneuploidy in the Generation of Cancer-Associated Differential Gene Expression Patterns
White Paper This paper tells about a search for evidence that aneuploidy is a major cause of differential gene expression. It describes how mutual information analysis of cancerassociated gene expression patterns could be exploited to answer this question. [03 Jul 2008]
Percolation Clustering: a Novel Algorithm Applied to the Clustering of Gene Expression Patterns in Dictyostelium Development
White Paper It is probabilistic in nature and allows each gene to belong to multiple clusters. Finally, it applies the algorithm to the gene expression data obtained from Dictyostelium development, and describes new findings which are of biological interest. [03 Jul 2008]
A Structure-Based Approach for Prediction of Protein Binding Sites in Gene-Upstream Regions
White Paper The challenge of identifying DNA regulatory sequences based on sequence information only has been emphasized in view of the fast accumulation of new genes in the databases. While most predictive algorithms are based on multiple alignments of... [03 Jul 2008]
Detecting Gene Relations from MEDLINE Abstracts
White Paper This article presents a simple analysis and knowledge discovery method that can identify related genes as well as their shared functionality (if any) based on a collection of relevant retrieved relevant MEDLINE documents. [03 Jul 2008]
Predicting Gene Function from Gene Expressions and Ontologies
White Paper Functional genomics studies gene function on a large scale by conducting parallel analysis of gene expression for a large number of genes. This research is a natural successor to the ongoing genome sequencing efforts such as, for example, the Human... [03 Jul 2008]
A Nonparametric Scoring Algorithm for Identifying Informative Genes from Microarray Data
White Paper Microarray data routinely contain gene expression levels of thousands of genes. In most cases, while the gene expression levels are available for a large number of genes, only a small fraction of these genes may be informative in classification... [03 Jul 2008]
BioProspector: Discovering Conserved DNA Motifs in Upstream Regulatory Regions of Co-Expressed Genes
White Paper The development of genome sequencing and DNA microarray analysis of gene expression gives rise to the demand for data-mining tools. BioProspector, a C program using a Gibbs sampling strategy, examines the upstream region of genes in the same gene... [03 Jul 2008]
Relevance Networks—a Powerful Bioinformatics Analysis Method in Functional Genomics
White Paper Relevance Networks is an algorithm that compares gene expression patterns in a multi-dimensional, clustering view showing the positive and negative relationships of genes within a cluster, and their participation in more than one pathway. [03 Jul 2008]
Genomics: the Second Stage of the Revolution
White Paper The identification of raw gene sequences has limited commercial value, because patents on genes will be issued only when the function of the gene and its implication in diseases pathology have been demonstrated. [03 Jul 2008]
Alternatives to the Use of Animals for Research, Testing and as Sources of Bioengineered Products
White Paper It is most likely that animal studies will remain essential for studying gene-gene and gene-environment interactions and for assessing the consequences of therapeutic intervention. This paper focuses on the manner in which requirements for the use... [03 Jul 2008]
Monsanto Processes 50% More Genetic Data Per Day With Platform
White Paper Monsanto was using its largest mainframe to run gene discovery applications, but advances in genomics tools and lab processes resulted in more data being generated for processing than the mainframe could handle. [03 Jul 2008]
A Strategy to Neutralize the Threat of Bioterrorism
White Paper The new technology that makes this possible is a particular type of plant science known as Transient Gene Expression (TGE). It is widely assumed that one cannot realistically hope to vaccinate the US civilian population against all possible... [03 Jul 2008]
